The proinflammatory cytokine IFN-γ is an important player in the antitumoral immune response and may further enhance therapeutic effects of a T cell-based immunotherapy as it increases MHC class I expression and antigen presentation of tumor cells and further supports macrophages, cytotoxic T lymphocytes and natural killer cells in their antitumor response. The gene discussed is IFNG; the disease is neoplasm.