PSCA and Familial prostate cancer: PSCA is a TAA upregulated in several major cancers, including prostate cancer, urinary bladder cancer, renal cell carcinoma, pancreatic cancer, ovarian mucinous tumor and NSCLC (Amara et al., 2001; Argani et al., 2001; Cao et al., 2005; Elsamman et al., 2006; Kawaguchi et al., 2010).