KEGG pathway enrichment analysis revealed that C. paliurus may exert its inhibitory effect on hepatocellular carcinoma by regulating pathways related to cancer (hsa05200), PI3K-Akt signaling pathway (hsa04151), proteoglycans in cancer pathway (hsa05205), microRNAs in cancer pathway (hsa05206), and endocrine resistance pathway (hsa01522) via core target proteins. Here, PIK3CA is linked to cancer.