KEGG pathway enrichment analysis revealed that C. paliurus may exert its inhibitory effect on hepatocellular carcinoma by regulating pathways related to cancer (hsa05200), PI3K-Akt signaling pathway (hsa04151), proteoglycans in cancer pathway (hsa05205), microRNAs in cancer pathway (hsa05206), and endocrine resistance pathway (hsa01522) via core target proteins. This evidence concerns the gene PIK3CA and hepatocellular carcinoma.