Also, the dysfunction of the KCNJ10 protein, Kir4.1, is associated with a number of neuronal phenotypes in several syndromic or non-syndromic neurodevelopmental disorders presenting with broad clinical manifestations and encompassing movement disorders and intellectual disability, besides ASD and seizures (Sicca et al., 2016). This evidence concerns the gene KCNJ10 and neurodevelopmental disorder.