NNMT and malignant colon neoplasm: Further comparison of NNMT protein expression according to the CPTAC database from UALCAN demonstrated that NNMT protein expression levels were significantly higher in advanced tumor tissues than in normal tissues; this was observed in breast cancer, colon cancer, glioblastoma multiforme, HNSC, KIRC, and pancreatic adenocarcinoma (PAAD) (Figure 1(c), all P < 0.001).