In contrast, decreased expression of NNMT was found in bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), cholangiocarcinoma (CHOL), kidney chromophobe (KICH), liver hepatocellular carcinoma (LIHC), lung squamous cell carcinoma (LUSC), and thyroid carcinoma (THCA) (Figure 1(b)). This evidence concerns the gene NNMT and cholangiocarcinoma.