Specifically, NNMT expression levels were significantly elevated in colon adenocarcinoma (COAD), head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), and stomach adenocarcinoma (STAD); these results were consistent with those in the Oncomine database. The gene discussed is NNMT; the disease is colon adenocarcinoma.