In fact, increased NNMT expression was associated with primary tumor size, lymph node metastasis, distant metastasis, and TNM stage in gastric cancer [19] and with increased tumor stage, grade, and mesenchymal molecular subtype in ovarian cancer [20] which indicated that NNMT might promote the growth and progression of cancer. Here, NNMT is linked to metastatic malignant neoplasm in the lymph nodes.