Other studies have reported that HIF induced the release of proinflammatory and proangiogenic substances by breast cancer cells, adipocytes, infiltrating CD8+ T cells, and other stromal cells, suggesting an intricate interplay between HIFs, proinflammatory factors derived from tumor and various TME cells, and angiogenesis that has yet to be fully elucidated (43, 44), and HIF1AN may also regulate angiogenesis and tumor microenvironment through chemokines and cytokines. This evidence concerns the gene CD8A and neoplasm.