CD274 and neoplasm: In the last years, the role of PD-1 and its ligand [programmed death ligand 1 (PD-L1)] has been studied in nccRCC patients; although the prognostic value of PD-L1 positivity in nccRCC remains unclear, it seems that PD-L1 expression in nccRCC is related to tumor aggressiveness (16–19).