Overexpressing NDRG1 rescued the enhanced EMT process of PKCδ, decreased the invasion and migration ability of RKO cells, upregulated the epithelial marker and downregulated the mesenchymal marker, which indicating that PKCδ could inhibit NDRG1 to promote EMT to enhance the invasion and migration ability of CRC cells. Here, PRKCD is linked to colorectal carcinoma.