Asparagine is a nonessential amino acid involved in protein synthesis for normal cells, which can be obtained from food or produced by the combination of aspartate acid with ammonia catalysed by asparagine synthase (ASNS) (16, 17).Different from normal cells, due to the lack of ASNS, leukaemia cells frequently fail to synthesize asparagine and therefore must rely on the host to supply asparagine for their protein synthesis requirements. Here, ASNS is linked to leukemia.