These findings, together with our results, we speculate that the identified DE-miRNA (such as hsa-miR-21-5p, hsa-miR-320c, hsa-144-3p/5p, hsa-miR-4454, hsa-miR-582-5p) and DEPs (such as angiogenin, Ras-related protein Rab-11B, kinase suppressor of Ras 1, complement C1q subcomponent subunit B, claudin-5) may be involved in the development of HCC. This evidence concerns the gene CLDN5 and hepatocellular carcinoma.