Consistent with scRNAseq analysis, the MUC16 overexpressing samples (n = 22; Z-score > 1) of the TCGA-PAAD cohort (n = 176) showed overexpression of genes regulated by TP63 (ENCODE/CHEA; p < 0.05) (Figure 3C; Supplementary File 1). Here, MUC16 is linked to pancreatic adenocarcinoma.