In parallel, the scRNA data from 15 PDAC tissues samples also showed higher infiltration of cells expressing SMC/fibroblast markers (PDPN, COL5A1, COL22A1, TIMP3, SPARC, WT1, GFPT2) in samples with higher proportions/fractions of MUC16-expressing tumor (epithelial) cells (n = 7) (Figure 2A). Here, COL22A1 is linked to neoplasm.