The transcriptome profile of KPCM tumor tissues (n = 3; 25-week-old) did not demonstrate changes to panCAF marker Podoplanin (Pdpn) but showed significant downregulation of genes involved in cytoskeletal, smooth muscle contraction, myofibril organization and focal adhesion (p < 0.05) relative to age-matched KPC (n = 3; 25-week old) PDAC samples (Figure 2B). Here, PDPN is linked to neoplasm.