The analysis using histological subtypes of QCMG-PAAD cohort (n = 96) pointed to significant overexpression of MUC16 in de novo adenocarcinomas (n = 70) and adenosquamous (n = 7) cancers compared to PDAC-originated from Intraductal Papillary Mucinous Neoplasms (IPMNs) (n = 12) (Figure 3G). This evidence concerns the gene MUC16 and pancreatic intraductal papillary-mucinous neoplasm.