Due to the homology of SFPQ and NONO gene, we classified Xp11.2 tRCC harboring SFPQ-TFE3 and NONO-TFE3 as a group and compared the characteristics of this group with non-DBHS family group (cases with PRCC-TFE3 and ASPL-TFE3 fusion). This evidence concerns the gene TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.