The herein reported overrepresentation of the TRBV12-3, TRBV29-1, TRBV19, TRBV5-1 and TRBV6-5 genes has been previously described in CLL and can be explained by naturally occurring convergence also observed in the TR gene repertoires from healthy T cells (16, 42). Here, TRBV19 is linked to B-cell chronic lymphocytic leukemia.