They also found that although the NUDT21 KD in HeLa Cells and the TCGA breast cancer carry a distinct set of 3′ US genes, they change the target sites of the common miRNAs (tamoMiRNA), suggesting that the APA initiated tumorigenesis is attributable to the miRNA target site changes, not the APA events themselves (51). This evidence concerns the gene NUDT21 and breast carcinoma.