CD4 and hepatocellular carcinoma: It is enriched in FOXP3+CD4+T, PDCD1+CD8+, and GZMK+CD8+T cells, affects the immune microenvironment of HCC by regulating the expression of target genes JAK2, SLC6A6, KCND1, MEIS3, and RIN1, and participates in the immune escape process in HCC (46).