NOS2 and Sepsis: In addition, VitC prevents endothelial-type nitric oxide synthase (eNOS) production, reduces protein phosphatase 2A activity, inhibits vascular leakage, and attenuates vascular endothelial barrier dysfunction by preventing eNOS uncoupling (superoxide anion production), reducing inducible nitric oxide synthase, and neural-type nitric oxide synthase activity and endothelial permeability [40], and reversing vascular hyporesponsiveness and hypotension in patients with sepsis [41].