TAAR1 and endothelial dysfunction: The use of Tα1 in the early stages of sepsis regulates immune function, attenuates overreaction, prevents immunosuppression, and avoids or mitigates secondary strikes, while the use of VitC, which inhibits the expression of superoxides in microvascular endothelial cells, reduces endothelial oxidative stress and improves endothelial dysfunction and microcirculatory disorders [38].