In the present study, the inflammatory response to sepsis in rats was differentially reduced and immune function was differentially modulated after Tα1 and/or VitC intervention, and these outcomes were accompanied by reductions in the proportions of CD4 + CD25 + T cells and DCs and reductions in the inflammatory cytokines IL-6, TNF-α, TGF-β1, and NF-κB (P65). The gene discussed is TNF; the disease is Sepsis.