In addition, high mobility group protein B1 (HMGBl) triggers the inflammatory response by increasing the release of inflammatory factors (such as TNF-α, IL-1, IL-6, IL-8, and macrophage inflammatory protein 1B), and changes in HMGBl levels are significantly correlated with the prognosis of patients with sepsis [17,18]. This evidence concerns the gene IL1B and Sepsis.