In the course of sepsis, DCs first transfer to the antigen epitopes of neutrophils, macrophages, and T helper lymphocytes (Th), activate NF-κB, enter the nucleus and form a complex with DNA, induce cell apoptosis, and release numerous proinflammatory cytokines and chemokines, such as TNF-α and IL-6. The gene discussed is NFKB1; the disease is Sepsis.