Targeting miRNA-155 with a locked nucleic acid-modified oligonucleotide, named cobomarsen (MRG-106), inhibited JAK/STAT/MAPK/ERK and PI3K/Akt signaling pathways and activated apoptosis in mycosis fungoides and human lymphotropic virus type 1 cutaneous T cell lymphoma cell lines.275. Here, AKT1 is linked to mycosis fungoides.