PADI1 and neoplasm: The ONCOS-210 and ONCOS-212 oncolytic adenoviruses, which express both PADI1 and TIMP2, and the combination (ONCOS-207 + ONCOS-209) significantly inhibited A2058 tumor growth in the nude mouse model compared with the vehicle-treated group and the single-transgene vectors ONCOS-207 and ONCOS-209.