In addition, there are also a variety of key cytokines involved in the pathogenesis of RA exacerbating and maintaining inflammation This study found that HIF-1α interference and low, medium, and high doses of Jinwujiangu prescription and sinapine could reduce the contents of CXCL8, CCL20, TNF-α, IL-1, IL-6, and IL-17. This evidence concerns the gene TNF and rheumatoid arthritis.