Interestingly, in the previous classification based on genetic heterogeneity (3), the BCL2 SVs were associated with poor outcomes of GCB-DLBCLs and PI3K with good-risk GCB-DLBCLs, while BCL2 was considered in the EZB subtype of DLBCL with favorable outcomes in another genetic classification (56). Here, BCL2 is linked to diffuse large B-cell lymphoma.