Cardiac DMT1 protein levels in rats increased in iron deficiency and decreased in iron overload (Ke et al., 2003), while blocking DMT1 in mice reduces heart iron deposits, free radical production, and iron concentration, suggesting that DMT1 can help facilitate TBI iron uptake in this tissue (Davis and Bartfay, 2004; Kumfu et al., 2011). Here, SLC11A2 is linked to Tangier disease.