Recently, biologics predominantly targeting TNF-<i>α</i> is employed for difficult-to-treat SAPHO cases; however, he had been complicated with the lesions of the central nervous system resembling multiple sclerosis (MS), an inflammatory demyelinating disorder in the central nervous system, for which application of TNF-<i>α</i> inhibitor is contraindicated. This evidence concerns the gene TNF and myeloid sarcoma.