CXCR4 expression and its effect on osteosarcoma patient’s overall survival was assessed in 8 studies that yielded a pooled HR 2.13 (95%Cl = 1.78–2.55, p < 0.001), meaning patients with high CXCR4 expression had a worse prognosis. The gene discussed is CXCR4; the disease is osteosarcoma.