In 2016, Fan and colleagues reported an upregulated ACAT1 activity despite comparable gene and protein expression in human leukaemia cells, head and neck cancer and lung cancer cells, compared to their corresponding normal cells [6], suggesting that an altered ACAT1 activity could occur without any differences in ACAT1 protein expression (OSCClow/Normallow and OSCChigh/Normalhigh). Here, ACAT1 is linked to lung carcinoma.