The main limitation of this study was the evaluation of other ketolytic enzymes including 3-hydroxybutyrate dehydrogenase 1(BDH1), 3-hydroxybutyrate dehydrogenase 2 (BDH2) and succinyl CoA: 3-oxoacid CoA transferase 1 (OXCT1) in the tumour and pre-tumour tissues of the OSCC patients. This evidence concerns the gene BDH1 and neoplasm.