ACAT1 and neoplasm: Since the expression levels of ACAT1, one of the key enzymes in the ketone body metabolic pathway, are variable between OSCC patients, a high-fat low-carbohydrate diet (ketogenic), which increases the amount of blood ketone bodies, would probably not be able to disrupt the metabolism and therefore would not increase the death of oral squamous cancer cells in all OSCC tumours.