MAPT and Alzheimer disease: To date, the neuropathological features of AD are thought to involve excessive amyloid β (Aβ) aggravation, hyperphosphorylation of Tau-induced neurofibrillary tangles (NFTs), and neuronal damage (Jeong, 2017; Ma et al., 2017; Reiss et al., 2018; Naseri et al., 2019).