In addition, in a mouse model of Alzheimer’s disease (AD), it has been reported that the expression of the mitochondrial transport and dynamics regulator Miro2, which is degraded through PINK1/Parkin-dependent mitophagy (Saotome et al., 2008; Shlevkov et al., 2016), was decreased in Nestin-positive cells of the hippocampus (Woo et al., 2021). This evidence concerns the gene NES and Alzheimer disease.