It has been also suggested that SIRT3 plays a role in ALS, as its overexpression protects against SOD1G93A-induced mitochondrial fragmentation and neuronal cell death (Song et al., 2013), in agreement with other works showing SIRT3 protection against aging-linked apoptosis in mice and excitotoxic insults in cultured neurons (Lee J. et al., 2012), although the exact mechanism remains elusive. The gene discussed is SIRT3; the disease is amyotrophic lateral sclerosis.