Moreover, a significant relationship between increased amyloid β and phosphorylated tau levels and worsened cognitive deficits were detected among the four groups (Figures 6G, H, r2 = 0.96 and 0.97 for the amyloid β level and r2 = 0.95 and 0.94 for the tau level and the mean escape time and discrimination index, respectively, all p < 0.05, n = 20). Here, MAPT is linked to Cognitive impairment.