Based on the above prognostic analysis, Kaplan-Meier survival curve revealed that the OS rate of sarcoma patients with high expression of EIF4A1 (HR = 1.64, p = 0.016), EIF4G3 (HR = 2.52, p = 0), NCBP1 (HR = 1.74, p = 0.007) and WDR4 (HR = 1.98, p = 0.001) was lower. The gene discussed is WDR4; the disease is sarcoma.