To better describe the mutations of the main driver genes of hepatocellular carcinoma (HCC), we screened the top 40 genes with mutation frequency from the somatic mutation data in the ICGC database and the TCGA database, including the four cohorts of ICGC-LICA-CN, ICGC-LICA-FR, ICGC-LIRI-JP and TCGC-LIHC, respectively, among which TTN, TP53, OBSCN, APOB, ADGRV1, XIRP2, PCLO, CSMD1, USH2A, LRP1B, FAT3, CSMD3, RYR2, and HMCN1 are repeated in four HCC queues (Figures 1A–D). The gene discussed is XIRP2; the disease is hepatocellular carcinoma.