TP53 and neoplasm: TP53 mutations lead to the loss of function of the wild type p53 and deprive cells of innate tumor inhibitory response; TP53 mutations can promote tumor cell survival and adapt to various internal and external stress conditions, including overproliferation-related DNA damage, oxidative and protein toxic stress, nutritional fluctuations, physical constraints, matrix cues, and anti-tumor immune responses (Senft and Ze’ev, 2016; Mantovani et al., 2019).