In the enriched signaling pathways (p-value <0.10; Table 4), we identified genes such as mitochondrial-encoded NADH dehydrogenase 5 (ND5 MTND5) and mitochondrial-encoded NADH dehydrogenase 6 (ND6 MTND6) that are present in the “CREB1-dependent transcriptional deregulation pathway in Huntington’s disease” (Supplementary Figure S2). Here, CREB1 is linked to juvenile Huntington disease.