In the high risk stratification of APE, when the volume of thrombus in the pulmonary artery is large, it will lead to a sharp increase in pulmonary artery pressure, increase the right heart load and right ventricular traction, and lead to cardiopulmonary circulation disorders, leading to a decrease in cardiac output and blood oxygen supply (13), leading to a significant increase in serum BNP and TnI levels. The gene discussed is NPPB; the disease is apparent mineralocorticoid excess.