We demonstrated that (i) Bre alleviated glomerular injury in DN mice, (ii) Bre alleviated HG-induced podocyte apoptosis and podocyte injury, (iii) Bre alleviated NF-κB/NLRP3-mediated pyroptosis in HG-treated podocytes, and (iv) Bre alleviated HG-induced podocyte injury by inhibiting NLRP3-mediated pyroptosis. This evidence concerns the gene NFKB1 and liver dysplastic nodule.