However, one study showed that capsaicin inhibits SIRT1 to enhance the acetylation of unc-51-like autophagy activating kinase 1 (ULK1) to trigger autophagy in oral cancer cells (Chang et al., 2020), which suggests that SIRT1 may inhibit autophagy in oral cancer cells. This evidence concerns the gene SIRT1 and lip and oral cavity carcinoma.