However, one study showed that capsaicin inhibits SIRT1 to enhance the acetylation of unc-51-like autophagy activating kinase 1 (ULK1) to trigger autophagy in oral cancer cells (Chang et al., 2020), which suggests that SIRT1 may inhibit autophagy in oral cancer cells. The gene discussed is ULK1; the disease is lip and oral cavity carcinoma.