Interestingly, Yuan et al. unveiled that HIF-1α activated nod-like receptor protein-3 (NLRP3) inflammasome-mediated pyroptosis in microglia after TBI and promoted TBI-induced behavioral and cognitive deficits, which further enhanced our understanding of the detailed role of HIF-1α in secondary brain injury [36]. The gene discussed is HIF1A; the disease is Cognitive impairment.