Interestingly, Yuan et al. unveiled that HIF-1α activated nod-like receptor protein-3 (NLRP3) inflammasome-mediated pyroptosis in microglia after TBI and promoted TBI-induced behavioral and cognitive deficits, which further enhanced our understanding of the detailed role of HIF-1α in secondary brain injury [36]. Here, NLRP3 is linked to Cognitive impairment.