Liu and others modulated immunosuppressive tumor microenvironment (ITM) and overcome radioactivity by coupling the Toll-like receptor agonist TLR7/8a with a radiation-sensitive hydrogel (Smac-TLR7/8 hydrogel) to adjust TAMs repolarization from M2 type into M1 type (Zhang et al., 2022). Here, TLR7 is linked to neoplasm.