Among adult patients with SCD living in Africa, we found that the majority of miRNAs that are differentially expressed in response to HU treatment are functionally associated with HbF-regulatory genes, including BCL11A (miR-148b-3p, miR-32-5p, miR-340-5p, miR-29c-3p) (Mnika et al., 2019). The gene discussed is BCL11A; the disease is Schnyder corneal dystrophy.