Treatment of diffuse large B‐cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cell lines with 9‐cis‐retinoic acid (RA) and IFN‐α was found to exert therapeutic effects through the induction of CRT outgrowth, early HSP70/90 membrane exposure, CD47 downregulation, and enhanced HMGB1 secretion. The gene discussed is IFNA1; the disease is diffuse large B-cell lymphoma.