CD8A and acute myeloid leukemia: The list of characteristic myeloid malignancies includes myelodysplastic syndromes (MDS), chronic myeloproliferative neoplasms (MPN), and acute myeloid leukemia (AML).[137, 138] Peripheral blood from patients with AML can show an increase in CD3+ and CD8+ T cells and enrichment of Tregs compared to blood from healthy donors.