The derivatives of MIR497HG, miR‐497, and miR‐195, work together to inhibit PI3K‐AKT signaling by downregulating the five positive regulators of PI3K‐AKT signaling, indicating MIR497HG can serve as a prognostic factor for tamoxifen sensitivity in patients with ER+ breast cancer. Here, ESR1 is linked to breast cancer.