SIRT3 and pulmonary fibrosis: As shown in Figure 5(A), Sirt3 siRNA resulted in an ∼80% decrease in Sirt3 expression in the lung tissues, and Sirt3 knockdown blocked the protective effects of baicalein against BLM-induced pulmonary fibrosis, as evidenced by the decreased collagen deposition (Figure 5(B)), and the levels of hydroxyproline (Figure 5(C)), collagen I (Figure 5(D)), aSMA and fibronectin (Fig. S2A and B).