2021). Recent studies have demonstrated that epithelial progenitor cell dysfunction and cellular senescence, including epithelial and fibroblast senescence, were associated with the pathological development of IPF (Demaria et al. 2014; Lehmann et al. 2017). Hohmann et al. (2019) found that quercetin could attenuate BLM-induced lung fibrosis and injury by inhibiting fibroblast senescence and enhancing FasL- or TRAIL-induced apoptosis. Of note, Cui et al. (2018) demonstrated that baicalein could mitigate TGF-β1-mediated lung FMT differentiation through the inhibition of miR-21 expression. This evidence concerns the gene TGFB1 and idiopathic pulmonary fibrosis.