In addition, participants in the Q4 group were older; had the highest proportion of osteoporosis and arthritis; had the highest levels of family PIR, vitamin D intake, UA, Scr, HDL-C, serum Ca, and serum phosphorus; and had the lowest levels of DBP, BMI, waist circumference, FBG, fasting insulin, HbA1c, eGFR, ALT, and TG. This evidence concerns the gene INS and arthritic joint disease.