Moreover, murine DN2 with a known human NUP98-HOXD13 (NHD13) fusion transcript have a predisposition to transform into a highly aggressive AML with similar gene expression profiles of several human AML subsets, including those with NPM1 mutations, MLL fusions and NUP98 fusions (103, 104). This evidence concerns the gene NPM1 and acute myeloid leukemia.