GP6 and osteoarthritis: We identified three pathways that were significantly activated in continuously upregulated DEPs, namely, NRF2-mediated oxidative stress response, Fcγ receptor-mediated phagocytosis, and ferroptosis signaling pathway (Figure 5C), whereas three pathways were significantly inhibited in the continuously downregulated DEPs, namely, GP6 signaling pathway, wound healing signaling pathway, and osteoarthritis pathway (Figure 5D).