Phosphatidylserine released by apoptotic tumor cells could induce the polarization and accumulation of M2 macrophages via a STAT3-Jmjd3-IRF4 signaling axis (115); therefore, down-regulation of Jmjd3 by targeting the STAT3-Jmjd3-IRF4 axis may be a candidate approach for inhibiting the accumulation of M2 macrophages in tumor sites and remodeling the TME. The gene discussed is IRF4; the disease is neoplasm.