Multiple soluble tumor-derived products, such as the chemokines CCL2, CCL5 and the cytokines IL10 and TGFβ, etc., recruit tumor-associated macrophages (TAMs) (3–6) and myeloid-derived suppressor cells (MDSCs) (7) into the TME, and lead to the impairment of differentiation, maturation and function of dendritic cells (DCs) (8, 9). This evidence concerns the gene IL10 and neoplasm.