The PRC2 core complex is composed of four core subunits, i.e., EZH1/2, EED, SUZ12, and RBBP4/7 (van Mierlo et al., 2019), and non-conservative variants in these complexes have been shown to cause PRC2-related overgrowth syndromes: Weaver syndrome is linked to EZH2 variants (OMIM #277590; Gibson et al., 2012), Cohen–Gibson syndrome is related to EED variants (OMIM #617561; Cohen et al., 2015), and SUZ12-related overgrowth is linked to SUZ12 variants (OMIM #618786; Cyrus et al., 2019). Here, SUZ12 is linked to Weaver syndrome.