SUZ12 and Weaver syndrome: Each of these PRC2-related overgrowth syndromes presents with tall stature, macrocephaly, advanced bone age, and intellectual disability, and Weaver syndrome and SUZ12-related overgrowth have been linked to increased risk of hematological malignancies and other cancers (Tatton-Brown et al., 2018; Cyrus et al., 2019; Gamu and Gibson, 2020).