NFATC2 and B-cell non-Hodgkin lymphoma: One example outside of RDEO is the report of B-cell malignancy in aging Nfatc2 knockout (KO) mice before the discovery of the first human patient with homozygous LoF NFATC2 variant, who developed B-cell lymphoma as a young adult (May et al., 2014; Sharma et al., 2022).