COX7C and chronic kidney disease: In addition, studies have shown that COX7C is a key regulator in the physiological processes of numerous diseases, where upregulation of this gene is associated with the development of many cancer tumors (Wang et al., 2017; Wang et al., 2022) and its downregulation is a feature of many chronic kidney diseases (Zaza et al., 2013; Wu et al., 2020).