The results showed that metabolism-related pathways were concentrated in normal samples, whereas the allograft rejection, asthma, autoimmune thyroid disease, graft−versus−host disease, intestinal immune network for IgA production, T ype I diabetes mellitus were significantly enriched in the CKD group, suggesting that immune imbalance may be one of the main pathogenic mechanisms in the advancement of CKD. The gene discussed is CD79A; the disease is autoimmune thyroid disease.