A fundamental mechanism for the control of LDH-A via acetylation was revealed in a work by Di Zhao et al., and they confirmed that LDHA K5 acetylation might be a potential marker of pancreatic cancer initiation (Fantin et al., 2006; Zhao et al., 2013; Ye et al., 2021). Here, LDHA is linked to familial pancreatic carcinoma.