Similar with RP, AMD genotypes are also variegated, which include single nucleotide polymorphisms (SNPs) in vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF), complement factor H (CFH), and high-temperature requirement factor A1 (HTRA1) genes (Mori et al., 2010; Black and Clark, 2016; Battu et al., 2022). This evidence concerns the gene SERPINF1 and age-related macular degeneration.