Among the six LOXs isoforms (15-LOX-1, 15-LOX-2, 12S-LOX, 12R-LOX, eLOX3, and 5-LOX), 15-LOX-1 levels increase under pathological conditions in both human and mice following stroke (Yigitkanli et al., 2013; Watanabe et al., 2022). The gene discussed is ALOX15; the disease is stroke disorder.