MLF1 and acute myeloid leukemia: MLF1 has been initially described in the leukemic fusion protein NPM-MLF1, which is generated by a rare t(3;5)(q25.1;q34) chromosomal translocation in patients with acute myeloid leukemia (AML) (1), and implicated in the development of AML and myelodysplastic syndrome (MDS) (2).