In recent years, a novel subtype of HCC that expresses biomarkers of both HCC (e.g., hepatocyte-1) and cholangiocellular carcinoma (e.g., CK19 or CK7) has been proposed, the so-called “dual-phenotype hepatocellular carcinoma” [34, 35]. The gene discussed is KRT19; the disease is cholangiocarcinoma.