KRT19 and hepatocellular carcinoma: Due to the aggressive behavior of CK19(+) HCC, some researchers advocated that this molecular subtype of HCC should be categorized as an independent pathological entity, separating it from other phenotypes displaying features of cholangiocellular differentiation, for instance, cholangiocellular carcinoma and combined HCC-cholangiocarcinoma [9, 10].